Importance of Microencapsulation in Pharmacy
Microencapsulation, as the name implies, is a process for encapsulating or enclosing solids, liquids, or even gases in minute particles utilizing thin wall coatings. It is the technique of surrounding or coating very small droplets or particles of liquid or solid material with a continuous film of polymeric material. There is various importance of microencapsulation in pharmacy.
We can make small particles or microcapsules using this technology that have two components: a core that can be solids, liquids, or even gases, and a coat. As microcapsules are made up of two parts (core and coat), the nature of the core and coating materials determines the properties of the microcapsule.
The Reasons for Microencapsulation
Before knowing the Importance of Microencapsulation in Pharmacy you must know the reason behind it. There are several methods for delivering a medicinal chemical to the target region in a regulated and sustained manner. Using microspheres as drug carriers are one such method. Microspheres are free-flowing powders that are made up of proteins or synthetic polymers that are biodegradable in nature and have particle sizes of less than 200 micrometers.
Microencapsulation is the technique of surrounding or coating very small droplets or particles of liquid or solid material with a continuous film of polymeric material. There are numerous purposes for microencapsulation.
In some circumstances, such as protecting vitamins from oxygen deterioration, delaying evaporation of a volatile core, increasing the handling capabilities of sticky material, or separating a reactive core from chemical attack, the core must be segregated from its surroundings.
In other circumstances, such as the controlled release of medications or insecticides, the goal is not to entirely isolate the core but to limit the rate at which it departs the microcapsule. The issue could be as simple as disguising the core’s flavor or odor, or as complicated as improving the selectivity of an adsorption or extraction method.
Importance of Microencapsulation in Pharmacy:
The technique of microencapsulation has gained popularity primarily because of its potential applicability in a wide variety of situations. Micro-encapsulation is utilized in the pharmaceutical sector for the following purposes:
•Drugs that are released in a sustained or protracted manner, such as aspirin.
•Bitter medications can be masked by disguising their taste., e.g., acetyl-p-aminophenol and masking of unpleasant odors.
•Elimination of incompatibilities, e.g., eutectic substances stabilization of drugs sensitive to oxygen, light, moisture, e.g., vitamins A and K. Preparation of free-flowing powders.
•Vaporization of volatile medicines is avoided., e.g., carbon tetrachlorides and a number of other substances have been microencapsulated to reduce their odor and volatility.
•Changing chemical entities’ physical attributes, e.g., Oils may be encapsulated to produce free-flowing powders.
•Making it easier for one material to disperse in another, e.g., to stabilize emulsions.
•Changing the pace at which chemical reactants dissolve, e.g., to slow down the rate of a chemical reaction. Reducing the toxicity, e.g., the handling of fumigants, insecticides, herbicides, and pesticides.
•To decrease gastric and other GI tract irritations, many medications have been microencapsulated, e.g., sustained-release aspirin preparations have been reported to cause significantly less GI bleeding than conventional preparations.
•Microencapsulation can reduce the hygroscopic characteristics of core materials., e.g., sodium chloride.
•Microencapsulation has been used to shield the core components from the impacts of the environment., e.g., vitamin A palmitate.
Disadvantages of Microencapsulation
- Possible cross-reaction between core and shell material.
- Difficult to achieve continuous and uniform film.
- The shelf life of hygroscopic drugs is reduced.
4.No single microencapsulation process is adaptable to all core materials.
6. Economic limitations.
7. More production costs.
- What is microencapsulation in pharmacy?
Microencapsulation is a procedure in which a coating surrounds microscopic particles or droplets to create tiny capsules with beneficial qualities. The microcapsule’s encased material is known as the core, internal phase, or fill, while the wall is known as a shell, coating, or membrane.
- Why Vitamin A is microencapsulated?
Vitamin A has a low water solubility and is chemically unstable. The stability of vitamin A may be aided by microencapsulation. Vitamin A can help you for better health. Vitamin A microencapsulation is very important for pharmacy.
- What is Micro Encapsulated Vitamin D?
Heat-stable microencapsulated vitamin D3 is meant to make it easier to incorporate into cooked foods or blends. When the molecules are freed from the encapsulating medium, they revert to their original shape. They pass via the small intestine and into the circulation.
- What is the most common method of microencapsulation?
The most popular microencapsulation method, spray drying, has been used for many years to encapsulate primarily flavors, lipids, and pigments. However, its use in thermo-sensitive products, such as microorganisms and essential oils, is limited due to the required high temperature, which causes volatilization.
There are various applications of microencapsulation in pharmacy. Some basic importances of Microencapsulation in Pharmacy are discussed in the above article. The demands for microencapsulation are growing day by day. More research is needed about this new drug delivery system.